The OPTimized Integrated MUltidisciplinary Systems (OPTIMUS) program will bring new coupled systems (actuation, power, thermal, engines) to the Multidisciplinary Optimized MDO conceptual design space for high speed aircraft such as next generation air dominance aircraft. The desired outcome is enhanced MDO methods, integrated operational analyses, geographically distributed design, and demonstration of the work on a Future Air Dominance conceptual design. Some key issues include looking at key coupled aircraft systems earlier in the design process, and defining what fidelity is needed at various milestones in the process. In addition, the development of distributed co-design/simulation is expected. Optimization parameters shall be tied to focused mission level assessment methods. This is a two-step BAA, and the first step cannot be submitted via Grants.gov. The second step (full proposal) may be submitted via Grants.gov.